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  • Continued Concern of Parent Vessel Steno-Occlusive Progression with Onyx HD-500 and the Utility of Quantitative MRI in Serial Assessment

    Final Number:

    Andrew P. Carlson MD, MSCR; Ali Alaraj MD; Sepideh Amin-Hanjani MD, FAANS, FACS, FAHA; Fady T. Charbel MD; Victor Aletich

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2012 Annual Meeting

    Introduction: Onyx HD-500 is an alternative endovascular treatment in selected cerebral aneurysms. Widespread use is limited by technical demands and by competing advances in flow diversion technologies. Parent vessel steno-occlusive progression is reported, however the etiology and management is controversial.

    Methods: Medical records of patients treated with Onyx HD-500 were retrospectively reviewed under IRB approval at the University of Illinois at Chicago for 2008-2011. Clinical and radiographic evaluations were assessed.

    Results: 17 patients underwent treatment of unruptured ICA aneurysms with Onyx HD-500. Three patients (17.6%) developed visual symptoms post procedure: 2 permanent, and one temporary. Four patients (23.5%) developed delayed ICA stenosis at 6-8 month follow-up angiography despite a standard regimen of antiplatelet medication. Quantitative MRI (Q-MRI) was obtained on all of these patients. One slowly progressed to complete but asymptomatic ICA occlusion with stable MCA flow. The second developed asymptomatic 40% stenosis with normal flow values. The third patient had transient delayed worsening to 70% stenosis, proximal to the aneurysm neck with normal flow which returned to near baseline by 27-month follow-up. The fourth patient developed critical stenosis 5mm distal to the aneurysm neck and possible TIA. Q-MRI showed decreased MCA flow and angioplasty was performed with improvement in vessel caliber and increased flow. Repeat Q-MRI 11 months later demonstrated progressive reduction in MCA flow and angioplasty with stenting was performed. Prolonged dual antiplatelets were continued in 2/4 patients, one with progression of stenosis and one with improvement of stenosis.

    Conclusions: We observed a higher rate of delayed parent vessel steno-occlusive progression with Onyx HD-500 than reported despite overall low morbidity. In two cases, the stenosis involved a carotid segment separate from the aneurysm neck. The role of prolonged dual antiplatelet therapy in these patients is not clear. Quantitative vessel flow imaging was useful in management and decision-making.

    Patient Care: Being aware of the presence of this delayed complication and how it is managed will improve safety of Onyx aneurysm embolization.

    Learning Objectives: 1- Understand that Onyx embolization of aneurysms is associated with a risk of delayed parent vessel occlusion 2- Describe the potential role of Quantitative MRI in serial assessment of these patients


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