Skip to main content
  • Related Quality of Life Outcomes with Minimally Invasive Transforaminal Lumbar Interbody Fusion Based on Long-Term Analysis of 318 Consecutive Patients

    Final Number:

    Mick J. Perez-Cruet MD MS; G. Zachary White BS; Evan M. Begun B.S.; Robert A Collins

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2012 Annual Meeting

    Introduction: Long-term prospective outcomes in patients undergoing minimally invasive spinal fusion for debilitating back pain has not been well studied.

    Methods: 318 patients (mean age 62.7, range 19-94) who underwent MITLIF were followed for 7 years. Patients presented with lumbar spondylolisthesis (236, 74%) and degenerative disc disease (82, 26%). Health care quality of life measures included Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Short From (SF-36).

    Results: 196 females and 122 males were treated. Levels fused included L1-2 (n = 3, 1%), L2-3 (n = 19, 6%), L3-4 (n = 34, 11%), L4-5 (n =163, 51%), L5-S1 (n = 89, 28%), or multi-level instrumentation (n =10, 3%). Estimated blood loss and hospital stay were 128.4 mL and 4.37 days. VAS scores decreased significantly starting at 6 weeks post-op. ODI scores declined from 44.1 preoperatively to 28.1 (p < .05) at one year, and 30.4 (p < .05) at 2-7 year period. SF36 physical component scores (PCS) increased from 30.3 preoperatively to 39.6 (p < .05) at one year, and 38.7 (p < .05) at 2-7 year period. SF36 mental component scores (MCS) increased from 43.7 preoperatively to 48.5 (p < .05) at one year, and 49.1 (p < .05) at 2-7 year period. Fusion rate was 100% at 2-year follow up. Re-operation rate for adjacent level disease was less then 2% over the 7 year period.

    Conclusions: This study presents a large long-term prospective outcomes analysis of MITLIF revealing statistically significant outcome improvements out to seven years. MITLIF resulted in a high rate of spinal fusion and very low rate of adjacent segment disease requiring re-operation. These results highlight the importance of focused surgery and attention to proper indications when selecting patients.

    Patient Care: This research will improve patient care by reducing patient risk and complications while reducing health care cost and improving outcomes.

    Learning Objectives: Review long term outcome analysis of minimally invasive spine fusion for chronic low back pain disorders. Understand patient selection and indications for MITLIF. Review techniques used in achieving outcomes.


We use cookies to improve the performance of our site, to analyze the traffic to our site, and to personalize your experience of the site. You can control cookies through your browser settings. Please find more information on the cookies used on our site. Privacy Policy