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  • Multimodality Management of Spetzler-Martin Grade III Arteriovenous Malformations

    Final Number:

    Paritosh Pandey MD; Ciara D. Harraher MD, BSc; Erick Michael Westbroeck; Michael P. Marks MD; Gary K. Steinberg MD, PhD

    Study Design:
    Clinical Trial

    Subject Category:

    Meeting: Congress of Neurological Surgeons 2011 Annual Meeting

    Introduction: Grade 3 AVMs are diverse due to variations in size(S), location in eloquent cortex (E) and presence of central venous drainage(V). These variations may have implications for management and outcome.

    Methods: 100 patients with grade 3 AVMs were treated from 1984 to 2010. AVMs were categorized as follows: Type 1, S1E1V1, Type 2 S2E1V0, Type 3 S2E0V1 and Type 4 S3E0V0. The occurrence of new deficit, functional status (mRS) at discharge and follow-up, and radiological obliteration were correlated with demographic and morphologic characteristics.

    Results: 100 patients (49f, 51 m, 5-68 years, mean 35.8 years) were evaluated. Size of AVMs were <3cm (28), 3-6 cm (71) and >6 cm (1); 86 AVMs were in eloquent cortex, and 38 had central drainage. The AVMS were type 1 (28), type 2 (60), type 3 (11) and type 4 (1). Embolization was performed in 77 patients (175 procedures), surgery in 64 patients (74 surgeries), and radiosurgery in 49 patients (44 primary, 5 postoperative). Mortality following the management of these AVMs was 1%. Fourteen patients (14%) had new deficits, with 5 (5%) disabling (mRS >2), and 9 (9%) non-disabling (mRS< 2) events. Patients with type 1 AVM (small AVMs) had the best outcome, with 1/28 (3.6%) having a new deficit as compared to larger AVMs (13/72, 16.7%, p<0.002). Older age(>40 years), size >3cm, and non-hemorrhagic presentation predicted occurrence of new deficits (p<0.002). Eighty-nine patients were included in the obliteration analysis. AVM was obliterated in 78 patients (87.6%). There was no difference between obliteration rates between types of AVMs, Size, eloquence and drainage or clinical presentation.

    Conclusions: Multi-modality management of Grade III AVMs results in a high rate of obliteration which isn't influenced by size, venous drainage or eloquent location. However, the development of new neurologic deficits did correlate with size, while eloquence and venous drainage did not influence this. We propose sub-classifying the grade III AVMs according to their size (<3 cm and >3 cm) to account for treatment risk.

    Patient Care: By identifying different types of grade 3 AVMs, it will be possible to individualize the treatment, and to predict the prognosis of different kinds of AVMs.

    Learning Objectives: 1. To identify different types of Grade 3 AVMs 2. To tailor the management according to the different types of grade 3 AVMs


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