Introduction: Background: Whole body hypothermia is an effective neuroprotectant in global cerebral ischemia. Selective hypothermia applied to focal cerebral ischemia produces moderate cerebral hypothermia with only mild systemic cooling. Utilizing a swine model of focal cerebral ischemia, we previously reported that selective hypothermia reduces stroke volume. An additional 5 animals have been tested using catheter based selective hypothermia, and an analysis of the entire cohort is presented.
Methods: Adult domestic swine were placed under general anesthesia. Transcranial occlusion of a proximal middle cerebral artery branch was performed for 3 hours followed by 3 hours of reperfusion. 17 animals had selective hypothermia induced during reperfusion utilizing a coaxial balloon catheter system. 13 animals were kept normothermic during reperfusion without intervention. Following 3 hours of reperfusion, the animals were sacrificed. Brain MRI and histology were performed independently and blinded to the intervention.
Results: Adult domestic swine were placed under general anesthesia. Transcranial occlusion of a proximal middle cerebral artery branch was performed for 3 hours followed by 3 hours of reperfusion. 17 animals had selective hypothermia induced during reperfusion utilizing a coaxial balloon catheter system. 13 animals were kept normothermic during reperfusion without intervention. Following 3 hours of reperfusion, the animals were sacrificed. Brain MRI and histology were performed independently and blinded to the intervention.
Conclusions: Selective hypothermia reduces stroke volumes in an adult swine model. Additional study of catheter based selective hypothermia is warranted.
Patient Care: Interventional stroke treatments may be enhanced by combining hypothermia with current recanalization techniques
Learning Objectives: Selective hypothermia reliably produces moderate depth hypothermia without significant systemic cooling
In an animal model, selective hypothermia reduces stroke size in both imaging and pathology