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  • Catheter Based Selective Hypothermia Reduces Focal Cerebral Ischemia in Adult Swine

    Final Number:
    225

    Authors:
    Thomas Mattingly MD, MSc; Amparo M Wolf MD PhD; Pablo Lopez-Ojeda MD, MSc; Lynn Denning; Karen Siroen; Barb Lehrbass; David Pelz; Donald Lee; Lee-Cyn Ang MD; Stephen P. Lownie MD

    Study Design:
    Laboratory Investigation

    Subject Category:
    Ischemic Stroke

    Meeting: AANS/CNS Cerebrovascular Section 2016 Annual Meeting

    Introduction: Background: Whole body hypothermia is an effective neuroprotectant in global cerebral ischemia. Selective hypothermia applied to focal cerebral ischemia produces moderate cerebral hypothermia with only mild systemic cooling. Utilizing a swine model of focal cerebral ischemia, we previously reported that selective hypothermia reduces stroke volume. An additional 5 animals have been tested using catheter based selective hypothermia, and an analysis of the entire cohort is presented.

    Methods: Adult domestic swine were placed under general anesthesia. Transcranial occlusion of a proximal middle cerebral artery branch was performed for 3 hours followed by 3 hours of reperfusion. 17 animals had selective hypothermia induced during reperfusion utilizing a coaxial balloon catheter system. 13 animals were kept normothermic during reperfusion without intervention. Following 3 hours of reperfusion, the animals were sacrificed. Brain MRI and histology were performed independently and blinded to the intervention.

    Results: Adult domestic swine were placed under general anesthesia. Transcranial occlusion of a proximal middle cerebral artery branch was performed for 3 hours followed by 3 hours of reperfusion. 17 animals had selective hypothermia induced during reperfusion utilizing a coaxial balloon catheter system. 13 animals were kept normothermic during reperfusion without intervention. Following 3 hours of reperfusion, the animals were sacrificed. Brain MRI and histology were performed independently and blinded to the intervention.

    Conclusions: Selective hypothermia reduces stroke volumes in an adult swine model. Additional study of catheter based selective hypothermia is warranted.

    Patient Care: Interventional stroke treatments may be enhanced by combining hypothermia with current recanalization techniques

    Learning Objectives: Selective hypothermia reliably produces moderate depth hypothermia without significant systemic cooling In an animal model, selective hypothermia reduces stroke size in both imaging and pathology

    References:

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