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  • Acquired Arteriovenous Malformations seen with Glioblastoma Multiforme: Report of an illustrative Case and Review of Literature

    Final Number:

    Ali S. Haider BS; Omar Choudhri MD

    Study Design:

    Subject Category:
    Vascular Malformations

    Meeting: AANS/CNS Cerebrovascular Section 2016 Annual Meeting

    Introduction: Reports of Arteriovenous malformations (AVMs) existing concurrently with gliomas as a Glioma-AVM complex are rare and there is currently a paucity of literature regarding underlying mechanisms and treatment paradigms.

    Methods: A rare and interesting case of AVM associated with glioblastoma multiforme is presented. A systematic literature review identifying all known pertinent cases along with reporting patient treatments, outcomes, and any interesting characteristics was performed.

    Results: One patient with a de-novo glioma associated with an AVM was described. The patient was confirmed to have a left parieto-occipital Spetzler-Martin grade I AVM concurrently with a left parietal brain tumor confirmed to be glioblastoma. Our literature review found a total of 8 cases, with 7 occurring in adults and 1 pediatric case. Only 1 case had received prior radiation and surgery was the most common form of treatment upon diagnosis. 3 cases were confirmed deceased after diagnosis and treatment.

    Conclusions: Though the vast majority of gliomas seen in combination with AVMs are SRS-induced malignancies, de-novo glioma associated AVMs do exist and represent a poorly understood phenomenon of AVM and Glioma morphology. Current standards of treatment include surgical resection and chemoradiation.

    Patient Care: This work illustrates the need for improved studies regarding the understanding and management of patients with de-novo gliomas associated with arteriovenous malformations and will thus aid in future studies on understanding AVM pathogenesis.

    Learning Objectives: 1) Describe relevant features and morphology of arteriovenous malformations and how they manifest with gliomas as part of a Glioma-AVM complex. 2) Describe the effectiveness of current treatment methods for Glioma-AVM complex.


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