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  • A Protocol for Withholding Prophylactic Antiepileptic Drugs in Seizure Naive Patients Undergoing Craniotomy for Tumor Resection

    Final Number:

    Madison Remick BS; Deborah A Cushing RN, MPH; Anand Rughani MD; Jeffrey Florman MD

    Study Design:

    Subject Category:

    Meeting: 2018 ASSFN Biennial Meeting

    Introduction: The use of prophylactic antiepileptic drugs (AEDs) in patients undergoing craniotomy for tumor resection is controversial. Published studies suggest that prophylactic administration of AEDs is unnecessary, especially in patients who are seizure free at the time of craniotomy. Based upon this literature, we hypothesized that cessation of prophylactic AEDs in patients undergoing craniotomy does not result in a significant increase in seizures. Our neurosurgical team implemented a protocol for withholding AEDs in seizure naive patents at the time of craniotomy for tumor resection.

    Methods: A chart review was performed in which we identified all patients undergoing craniotomy for tumor resection. From this cohort, we identified those from whom AEDs were prospectively withheld as well as those who were seizure free at the time of surgery. Patient data such as age, gender, tissue diagnosis, and seizure history were collected over a period from January 2013 through June 2017. The seizure incidence rates between individuals who did not receive prophylaxis were compared to matched controls who received AED therapy.

    Results: A total of 743 eligible patients were identified. After an initial chart review, 629 (317 female) underwent craniotomy for tumor resection. Of this cohort, a total of 397 (63%) patients had no prior history of seizure(s) at the time of tumor resection; of which 217 (55%) did not receive prophylactic AEDs. Of the seizure naive patients who did not receive AED prophylaxis, 7 (3.2%) experienced a postoperative seizure in comparison to 6 (3.3%) patients who were given prophylactic AEDs (p=0.58; Fisher exact test).

    Conclusions: From this dataset we observed no statistically significant difference in the incidence of new post-operative seizure(s) following implementation of our protocol when compared to controls who received AED therapy. This preliminary observation is intriguing and warrants further study in order to more accurately define the therapeutic index of prophylactic AED therapy.

    Patient Care: We are reporting preliminary data on the value of AED prophylaxis in brain tumor patients in the hopes of identifying a strategy that may improve their perioperative management.

    Learning Objectives: By the end of this session, participants should be able to: 1) Describe the importance of understanding the role of AED seizure prophylaxis in brain tumor patients, 2) Discuss, in small groups, the therapeutic index of these medications in patients who are seizure free at the time of surgery versus patients with a prior history of seizures, 3) Identify an effective protocol for determining if seizure naïve craniotomy patients significantly benefit from administration of AEDs.


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