The Role of Anticonvulsants
Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?
These recommendations apply to adults with solid brain metastases who have not
experienced a seizure due to their metastatic brain disease.
Level 3 For adults with brain metastases who have not experienced a seizure due to
their metastatic brain disease, routine prophylactic use of anticonvulsants is not
Only a single underpowered randomized controlled trial (RCT), which did not detect a
difference in seizure occurrence, provides evidence for decision-making purposes.