The Role of Anticonvulsants

The American Association of Neurological Surgeons & the Congress of Neurological Surgeons

Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?

Target population

These recommendations apply to adults with solid brain metastases who have not
experienced a seizure due to their metastatic brain disease.
 

Recommendation

Level 3 For adults with brain metastases who have not experienced a seizure due to
their metastatic brain disease, routine prophylactic use of anticonvulsants is not
recommended.
 
Only a single underpowered randomized controlled trial (RCT), which did not detect a
difference in seizure occurrence, provides evidence for decision-making purposes.